The start of the Final 64 gets underway today with 16 NCAA tournament second round games at four different sites including one involving the top overall seed.

That would be Florida which opens South Regional play later today against Albany in Orlando. The Gators will be trying to avoid becoming the first No. 1 seed in tournament history to be upset by a No. 16 seed.

Albany has already notched a tournament win, knocking off Mount St. Mary's in a First Four game Tuesday.

Defending national champ Louisville tips off against Manhattan. That's a match-up between Cardinals coach Rick Pitino and former assistant Steve Masiello.

President Obama's pick to win it all, Michigan State, opens play in Spokane against Colonial Athletic Association champ Delaware.

Former top-ranked Syracuse tries to stop its late season skid when it takes on Mid-American Conference champ Western Michigan in Buffalo. The Orange have stumbled down the stretch losing five of their last seven, including their opening game in the ACC tournament.

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