The No. 1 men's and women's seeds have moved into the fourth round of the U.S. Open.

Novak Djokovic (JOH'-koh-vihch) has advanced with a 6-3, 6-2, 6-2 rout of American Sam Querrey. Djokovic needed just 86 minutes to win the match and reach the round of 16 for the 22nd straight time in a Grand Slam tournament.

Serena Williams was a 6-3, 6-3, winner against fellow American Varvara Lepchenko. The two-time defending champ extended her overall winning streak at Flushing Meadows to 17 after conquering the windy conditions at Arthur Ashe Stadium.

Wimbledon champion and third seed Petra Kvitova (kuh-VIHT'-oh-vuh) is out after committing 34 unforced errors in a 6-4, 6-4 loss to Aleksandra Krunic (KROO'-neech) in the third round. Kvitova is the fifth player among the top eight women's seeds to be eliminated. The 145th-ranked Krunic is the seventh qualifier since 1977 to advance to the women's fourth round.

Joining Williams and Krunic into the fourth round were seventh seed Eugenie Bouchard (yoo-JEE'-nee boo-SHAHRD'), 11th seed Flavia Pennetta, No. 16 Victoria Azarenka and No. 17 Ekaterina Makarova , but No. 15 Carla Suarez Navarro was beaten by Kaia Kanepi in straight sets.

Men's fifth seed Milos Raonic (ROW'-nihch) won three straight tiebreakers to move into the fourth round. Eighth seed Andy Murray needed four sets to advance, third seed Stan Wawrinka (vah-VINK'-ah) won in a walkover, and No. 10 Kei Nishikori dropped just nine games in his straight-sets victory. No. 22 Philipp Kohlschreiber ousted No. 13 John Isner, 7-6, 4-6, 7-6, 7-6. Isner was the last American male still left in the tournament.

More From ESPN Western Colorado